Furthermore, the CNV regions used in our study were greater than 1 Mb in length. There might also be important genes in smaller regions or in deleted regions, which were not immediately available from the original publication. However, the CNV regions we used in the current study were directly from the original publication and were of high quality. Nevertheless, our convergent strategy was able to identify 20 highpriority genes within strong biological context. Inclusion of more complete datasets or other types of datasets in future will greatly improve the quality of the current work. In conclusion, we proposed a stepwise enrichment procedure to converge CNV genes by incorporating publically available highthroughput datasets. By applying a subnetwork construction algorithm, we established a subnetwork for CNV genes, as well as for a set of previously reported genes for epilepsy. The overlap between the two subnetworks constitutes a high-priority candidate gene set for epilepsy. Integration of additional gene expression data further narrowed the candidate gene list to two of special interest. This procedure is extensible to other disorders. Euvolemia is a predictor of outcome in peritoneal dialysis patients, as volume overload is related to cardiac dysfunction, inflammation and mortality. Euvolemia is probably a more important adequacy parameter than small solute clearance, as fluid status but not small solute clearance predicts outcome. Guidance on how to achieve and maintain euvolemia in individual PD patients is hampered by the absence of a convenient device to measure volume status, and by the lack of insight in the prevalence of and factors associated with volume overload. In clinical practice, the assessment of volume status is relatively crude. Volume status is often assessed indirectly by measuring fluid removal, failing to take into account fluid balance by omission of dietary fluid intake. Ultrasonic evaluation of inferior vena cava diameter only assesses intravascular volume, and is also influenced by diastolic dysfunction , and is thus a reflection of preload, and not of tissue hydration. Parameters, such as Brain Natriuretic Peptide or NT-proBNP can reflect changes in hydration status, but are also influenced both by preload and ventricular abnormalities, and in patients with renal failure, accumulation can occur. Direct measurement of CHIR-99021 extracellular and total body water by dilution methods is considered as the golden standard, but these techniques are laborious and expensive. Bio-impedance spectroscopy represents a different approach to the assessment of fluid status. By measuring the flow of electrical current through the body, resistance and reactance can be measured, and in BIS, this is performed at different frequencies. The Body Composition Monitor is a bio-impedance spectroscopy device for clinical use, validated by isotope dilution methods and has been used in hemodialysis and PD.