Valadi et al. firstly discovered the exosome-mediated miRNA transfer and promoted the notion that this would be a novel mechanism of genetic exchange between cells. Since then, their seminal finding has generated much enthusiasm in exploring the function of such process during resistance transmission. In the present work, we investigated whether A/exo and D/exo carried selective miRNA patterns that may account for the induction of malignant capacities for MCF-7/S growth and survival. Compared with S/exo, we found 374 differentially expressed miRNAs in A/exo and 307 aberrant miRNAs in D/exo, indicating that exosomes from drug-insensitive BCa cells were characterized by marked changes in miRNA content. At the same time, a large number of the miRNAs exhibited similar expression trends in both A/exo and D/exo, and the others either altered only in certain exosome or fluctuated in opposite directions. Our microarray analysis might suggest the existence of several common pathways as well as drug-specific molecular machineries in spreading resistance traits. Strikingly, while some miRNAs with consistent changes contributed to the cross-resistance, a few miRNAs displayed exclusively in A/exo or D/exo were responsible for the various degree of chemoresponse. In our opinion, the latter miRNAs are equally noteworthy because comprehensively profiling these miRNAs after using adr and doc, to some extend, would explain the different resistance mechanisms and help to choose an appropriate mono or combined therapeutic program. Our results would add another piece of evidence to the emerging idea that exosomes from drugresistant tumor cells are capable of delivering a subset of miRNAs to sensitive cells. In saying this however, we cannot exclude the possibility that increased miRNA levels in acquired cells are caused by either/both direct or indirect exosome-mediated effects on miRNAs. It is therefore desired that further attention be drawn to this field. Interestingly, Yuan et al. found that peak transfer occurred at nearly the same time between 12-36 h and they showed a significant downward trend at 54 h. We have not tested such observation at this time, but we can speculate that the efficiency of miRNA transfer may be different during co-culture. It is difficult to determine whether all the differentially expressed miRNAs have a major role in the process of resistance transmission. Instead, researchers shift the attention to explore the regulatory capacity of individual miRNAs whose targets are experimentally affirmed. One area of interest is the tritocerebral loop–which lies just ventral to the subesophageal ganglion – an area of dense innervations targeted by gustatory, protocerebral/neurosecretory, and stomatogastric inputs. Peripheral gustatory axons, from the mouthparts, subsets of the labellum, and stomatogastric nerves, target the tritocerebrum.