Allowed us to establish a regulatory circuit which is triggered effectively by the expression of an endogenous protein. This regulatory system can now be used as a model to set up signal transduction networks for peptide-mediated regulation of gene expression and thereby simulate biological signaling. This is gaining increased attention considering the many approaches used to obtain novel peptides that bind and regulate a target protein’s activity. Moreover, the Pcat -10CATTTA and Pcat -10CAGCCA mutants, as well as other promoter variants from our library, can be used in different genetic networks to fine-tune the expression of a respective target gene, thereby adding a new instrument to the genetic and synthetic engineering toolbox. The two main tumor sites of GC are cardia and noncardia. The cardia GC Folinic acid calcium salt pentahydrate affects five times more men than women. In addition, the incidence rates of cardia GC are relatively high in the professional classes. In contrast, the noncardia GC has a male-to-female ratio of approximately 2:1 and the incidence rises progressively with age, with a peak incidence between 50 and 70 years. Over the last few decades, the incidence of noncardia GC has substantially declined in developed 
regions of the world. However, this subtype still constitutes the majority of GC cases worldwide and remains common in many geographic regions, including China, Japan, Eastern Europe and Central/South Americas. The understanding of GC biology and the identification of cancer biomarkers are necessary to reduce the mortality rates through cancer screenings in high-risk populations, to increase early diagnosis, and to develop new target therapies. GC, as other neoplasias, is thought to result from a combination of environmental factors and the accumulation of generalized and specific genetic and epigenetic alterations, which affect oncogenes, tumor suppressor genes, and control genomic instability. Several genes/proteins have been proposed as GC biomarkers. In the multistage gastric carcinogenesis, alterations of the oncogenes MYC, KRAS2, CTNNB1, ERBB2, FGFR2, CCNE1 and HGFR, as well as of the tumor suppressors TP53, APC, RB, DCC, RUNX3 and CDH1 have been so far reported. Although the deregulation of these genes/proteins has been intensively studied in GC, a more complete profiling is necessary to understand the carcinogenesis process. The last decade in life sciences was deeply influenced by the development of the “Omics” technologies which aim to depict a global view of biological systems and the understanding of the living cell. Since proteins are ultimately responsible for the malignant phenotype, proteomic analyses may reflect the functional state of cancer cells, and therefore have distinct advantages over genomics and transcriptomics studies. Moreover, proteins are currently the main target molecules of anticancer drugs. Some proteomic-based studies were previously performed in human primary gastric tumors. However, most of these studies analyzed tumors of individuals from Asian population and, thus, may not reflect the distinct biological and clinical Orbifloxacin behaviors among GC processes. GC is marked by global variations in incidence, etiology, natural course, and management. Although, about 90% of stomach tumors are adenocarcinomas, several factors lead to biologically and clinically GC subsets: antecedent tumorigenic conditions, such as Helicobacter pylori gastritis and other chronic gastric pathologies; location of the primary tumor; subtypes of adenocarcinoma; ethnicity of the afflicted population; and a predictive biomarker. Thus, the term “gastric cancer” is used to describe several neoplasias that affect the stomach region. In the present study, we compared the expression profile of noncardia GC and the matched non-neoplastic gastric tissue of individuals from Northern Brazil.