Agent due to its activity against bacteria, yeast, and filamentous molds. So far, available experimental evidence suggests that antimicrobial action of CA involves cell wall synthesis, membrane action, and specific cellular processes. However, the defined targets of cinnamaldehyde in microbial have not well established yet, which requires more investigations in the early microbial responses to CA. Ca2+ is not only a universal intracellular second messenger in eukaryotic cells, but also is essential for multiple functions of cell compartments. The disruption of Ca2+ signaling/homeostasis is able to result in the inhibition of some fugal growth. The antifungal activity of CA has been attributed to its significant effect on ergosterol production. Individual variability in drug response can be attributable to factors such as age, gender, or environmental factors but genetic differences in particular, or even higher in some groups, of inter-individual differences in drug metabolism and response. Polymorphisms of the CYP enzymes have been widely identified, with two or more variant alleles. These AbMole Riociguat BAY 63-2521 variants in the DNA sequence of genes, to some extent, decrease, increase or completely abolish the enzyme activity. Individuals can be classified as extensive metabolizers, poor metabolizers, intermediate metabolizers and ultrarapid metabolizers according to their ability to metabolize drug substrates. The enzyme activity variability of CYP genes attributable to genetic factors can be used as a predictor for individualized therapy to improve clinical efficacy or avoid ADR. The relationship between specific CYP enzyme activity and its gene polymorphism has been widely studied. It has been shown that allele frequencies vary largely between different populations and geographic areas and a number of pharmacogenomics studies have investigated different drug metabolism genes in specific geographic areas and ethnic groups. Our own group has also conducted a gene polymorphism analysis of different CYP genes in the Chinese population. However, most of these studies have focused on single genes, drug metabolism usually involves multiple CYP genes. Multi-gene analysis is therefore important in drug response evaluation but, to date, no systematic combined genotype and functional combinations analysis of multiple CYP genes in different geographic areas for the same population has been undertaken. In the present study, we focused on analyzing the functional combinations of four major CYP genes CYP2E1, CYP2D6, CYP2C9 and CYP2C19 genes in different geographic areas in within the Chinese Han population. CYP3A4/5 was not among the genes studied since its enzyme variation is AbMole Metaproterenol Sulfate.