Taken together, these results suggest that in pediatric 4-(Aminomethyl)benzoic acid patients below the age of 15 other mutations than the classical 816 of the ckit gene may occur. Therefore, pathogenesis of mastocytosis clearly differs according to age��s onset. Prospective studies in pediatric population is currently performed to determine whether frequency of these unusual mutations might be a pronostic indicator. In conclusion, despite similar Indinavir sulfate clinical presentation, the high frequency of non mutated c-kit gene in case of childhood��s onset contrasted with a high frequency of 816 mutation in mastocytosis cases starting at the adult��s age. These findings may have important therapeutic implications when targeted therapy against kinase activity of c-kit is considered. Patients were included after written informed consent was obtained. The study was approved by the ethical committee of Pitie-Salpetriere university hospital and data were computerized in accordance with the French Commission Informatique et Liberte ��s. All patients had a histologically proven mastocytosis. In all cases skin biopsies and bone marrow biopsies/or aspiration were performed. The diagnosis of cutaneous involvement by mastocytosis was based on the association of both clinical symptoms compatible with cutaneous mastocytosis and the presence of a mast cells multifocal accumulation in skin biopsy according to usual histopathological criteria. In most of the cases TMEP doesn��t show a significant increase in mast cells and the diagnosis was made in association with clinical datas. Laboratory-based reporting systems would have generated 2648 reports of patients with hepatitis B without flagging the eight acute cases from the many more chronic cases. Patients were included if coronary artery disease was confirmed by angiography, performed after myocardial infarction or in the course of the study of angina pectoris. Exclusion criteria included serious systemic diseases, such as cancer and systemic infections. Patients were evaluated under a protocol which included electrocardiogram, echocardiogram and plasma measurement of total cholesterol.