EMT is a process in which cell adhesion properties are altered and epithelial cells lose their cell polarity and gain migratory and invasive properties to become mesenchymal cells. Indeed, the genes upregulated in the Spindle cell lines include 73 Extracellular matrix component genes as defined by Hynes et al. including several genes up-regulated during EMT. These morphological subtypes are observed in cell lines from multiple tumour types and seem to associate with (R)Ginsenoside-Rh1 characteristics of putative clinical importance. It is therefore important to translate the in vitro morphological phenotype to a clinical phenotype. We performed an in silico analysis to determine whether the three in vitro identified morphological subtypes associate with clinical characteristics including prognosis as well as the molecular subtypes identified within ovarian carcinomas. We normalized the cell line and carcinoma data separately to correct for differences Ginsenoside-Rd between the two platforms used. However, we cannot predict how this reflects the biological differences such as the presence of stroma, fibroblasts and immune cells within tumour tissue which is not present in cell lines. Clustering of the cell lines together with the endometrioid and HGS carcinomas using the morphology associated genes showed two tumour clusters, 1) the Spindle-like tumours, and 2) the Epithelial and Round-like tumours. ECM remodelling as well as EMT have been associated with invasion and metastasis and thus a clinically more aggressive subtype. Indeed, the Spindle-like tumour cluster showed a significant enrichment for metastases as arrayed site, higher stage, sub-optimal debulking, and decreased progression-free survival. The increased expression of cell movement and invasionassociated genes could explain the metastasis, higher stage and worse prognosis observed. We also found that the morphological tumour clusters were associated with the six molecular subtypes C1-C6 identified by Tothill et al.. Cluster 1 contains all C1 and most C3 carcinomas. The worse prognosis for the C1 subtype carcinomas previously observed by Tothill et al. thus explains the worse prognosis seen for the spindle-like cluster. Cluster 2 contains most C4, C5 and C6 tumours.