Using this Aprindine hydrochloride approach, we were able to successfully piece together a previously hidden relationship between 2 disparate fields and add to the overall knowledge base. Our Pyrabactin hypothesis concerning anandamide and gastric cancer was tested through the closed discovery process. This process was performed using the web-based model Arrowsmith; starting from the disease of gastric cancer and the substance of anandamide, we searched for common intermediate B-terms. The B-list contained title words and phrases that appeared in both the A and C literature. As the pathways found between A and C became more common, it increased the likely validity of our hypothesis. Following the necessary aforementioned filter steps, 446 terms were present on the current B-list, ranked according to predicted relevance. Next, we restricted these terms by semantic categories of Genes & Molecular Sequences and Gene & Protein Names and collected the target genes involved in different signaling pathways including cell cycle, apoptosis, inflammation and etc. Simultaneously a pathway network was constructed to display the common molecular regulatory network between gastric cancer and anandamide action. As seen in Figure 1, these genes exhibited high dependency indicating the regulatory relationships between them. To further examine the validity of these target genes, several proteins/genes were chosen as examples to verify their relationship to gastric cancer or anandamide through ARROWSMITH SYSTEM. And as shown in Table 5, a group of critical genes involved in several pathways that are linked both to gastric cancer and to anandamide. All of these clues implied a potentially hidden connection between anandamide and gastric cancer, which was worthy of further investigation. Anandamide, as a member of the endocannabinoid family, also known as N-arachidonoylethanolamine or AEA, was shown to activate 2 distinct G protein-coupled cannabinoid receptors, the cannabinoid receptor type 1 and the cannabinoid receptor type 2. Anandamide is synthesized from N-arachidonoyl phosphatidylethanolamine and its degradation is primarily catalyzed by the fatty acid amide hydrolase enzyme, which also catalyzes the downstream conversion of anandamide into ethanolamine and arachidonic acid. The structure of anandamide includes the functional groups of amides, esters, and ethers of long-chain polyunsaturated fatty acids.