It was first reported by Knorr et al. that ciprofloxacin could induce the prolongation of the Q-T interval. Later, many fluoroquinolone antibiotics were shown to prolong, the Q-T interval, which triggered an arrhythmia. Changing behavior is a comprehensive response to external and internal environmental changes. At an individual level, changes in biological behavior can reflect toxicological effects of environmental pollution on biological metabolism and the functions of nerve, muscle and organs. Jin et al. found that the insecticide bifenthrin increased the spontaneous movement frequency by prolonging repetitive action potential due to channel opening. In this research, the larvae exposed to 4.69 or 9.38-mg/L of DKAs had a higher swimming speed, suggesting that the lower DKA concentrations had an incentive MNI 137 effect on larval motor neuron function. Under conditions of light-to-dark stimulation, zebrafish behavior showed a regular biorhythm, i.e., first active after exposed to sudden darkness and then gradually becoming inactive. Based on the experimental results of the differentially expressed proteins, we speculated that the declining swimming ability of zebrafish may be due to abnormal muscle and innervation. Pseudomonas aeruginosa is a bacterium that survives in many diverse environments. Well known as both a clinically and environmentally relevant organism, much of P. aeruginosa growth in these different niches is perceived to be as surface-associated biofilms. The surface characteristics, not just the nutrient conditions, for these diverse growth environments are highly variable. We were interested to understand how P. aeruginosa SB 611812 freely colonizes such different surface environments. P. aeruginosa and many other bacteria, including species found in diverse soil and water environments such as Serratia liquefaciens, Vibrio cholerae, Vibrio parahaemolyticus, Proteus mirabilis, and Bacillus subtilis, colonize surfaces by swarming. Swarming is typically studied in the laboratory using semisolid plate assays. Swarming bacteria spread over surfaces by flagellar propulsion within a thin-liquid film layer on top of these agar plates. For most swarming bacteria, the spreading properties of this high-population liquid swarm layer are enhanced by production of a surfactant by the bacteria. Swarming can also occur without a surfactant;