Pancreatic cancer is the fourth leading cause of cancer related deaths in America, in both men and women. Despite vast efforts to detect and treat pancreatic cancer, the incidence and mortality rates remain virtually the same. Early diagnosis and efficient delivery of therapeutic agents to SEA 0400 malignant cells remain the two major challenges in cancer management strategies. Monoclonal antibodies against growth factor receptors have been shown to be viable treatments for inhibiting cancer growth. Utilizing these monoclonal antibodies as targeting agents for tumor specific delivery is evolving as a promising approach to selectively L-Serine deliver chemotherapeutics. Inorganic nanomaterials are being studied as the delivery vehicle for targeted drug delivery. Gold nanomaterials are of particular interest due to the unique physico-chemical and optoelectronic properties, ease of synthesis and surface modification. Gold nanoparticles have recently been used to kill tumor cells by hyperthermia using non-invasive radiofrequency. Their utility as a contrast agent has also been demonstrated by clear delineation of blood capillaries in a preclinical model by CT in comparison to the conventional iodine based contrast agents. Both studies are hopeful and their utility is further encouraged by the safety profile. Epidermal growth factor receptor is an important target in cancer research. It is overexpressed in a number of human malignancies including pancreatic cancer. Human EGFR is a transmembrane glycoprotein. It consists of an extracellular ligand binding domain, a hydrophobic transmembrane domain and an intracellular tyrosine kinase domain. Ligand binding to EGFR induces receptor homo/heterodimerization leading to the phosphorylation of tyrosine residues. Phosphorylation of EGFR activates complex down stream signaling events leading to proliferation, migration, invasion, and inhibition of apoptosis of cancer cells. The monoclonal anti-EGFR antibody, Cetuximab, is a unique targeting agent to target EGFR-positive cancer cells. Cetuximab was approved by the FDA for the treatment of patients with EGFR positive colorectal cancer. It has also been either approved or is in different phases of clinical trials in many other malignancies such as NSCLC, SCCHN and pancreatic cancer. Cetuximab is a chimeric human:murine immunoglobulin G1 monoclonal antibody.