Potassium bromate is a food additive that is extensively used as a maturing agent for flour and as a dough conditioner. It is also used in cosmetics and is a component of permanent hair weaving solutions. Disinfection of drinking water by ozonation, which has emerged as a promising alternative to chlorination since it does not result in the production of hazardous agents like trihalomethanes, also generates bromate as a by-product. During ozonation, the bromide contained in water naturally is oxidized to bromate which is thus frequently detected in tap and even bottled water. Exposure to KBrO3 results in multiple organ toxicity with kidney being the primary target organ of this compound. KBrO3 has been shown to alter gene expression in renal tissues and chronic administration of KBrO3 induces carcinomas in rats, hamsters and mice. Bromate is now considered as a probable human carcinogen and a complete carcinogen in animals. Increased production of reactive oxygen species and free SAR131675 radicals has been implicated in mediating KBrO3-induced toxicity. These radicals can cause extensive tissue damage by reacting with macromolecules like proteins, nucleic acids and membrane lipids which causes an imbalance in homeostasis and leads to tissue injury. Supporting the Crizotinib involvement of ROS in its action, several antioxidants have been shown to ameliorate the bromate-induced multiple organ toxicity. Taurine is a conditionally essential amino acid found in large concentrations in all mammalian tissues and accounts for approximately 0.1% of total human body weight. It is present in various foods like eggs, milk and is especially abundant in seafood and meat. Taurine is involved in a number of crucial physiological processes including modulation of calcium flux and neuronal excitability, osmoregulation, detoxification, membrane stabilization, reproduction and immunity. It is essential for the development and survival of mammalian cells, particularly those of the cerebellum, retina and kidney. Taurine is also an AO and a potent scavenger of the hydroxyl radical suggesting that it may be useful in treating oxygen radical mediated toxicity. Taurine protects tissues from various pathological conditions resulting from free radicals generated upon exposure to various xenobiotics. We have recently shown that administration of KBrO3 to rats induces oxidative stress and lowers the activities of several enzymes in the intestinal brush border membrane. It causes alterations in the activities of various antioxidant and metabolic enzymes and damages the intestinal DNA. In the present work, we have used taurine to attenuate the KBrO3-induced intestinal damage using rats as the animal model. This was done in view of the effectiveness of taurine in mitigating toxicities involving ROS and OS.