Further studies are needed to confirm the interconnection or explain the complex mechanisms among them. We have began a new study aimed at finding this potential mechanism by detecting the expression levels of other related molecules in multiple pathways involved in IGF, NF-kB, PI 3-kinase/Akt and Wnt/b-catenin pathways. In conclusion, we firstly reported Cholecalciferol p-Ser9-GSK-3b was an independent prognostic factor of patients with HCC and it might mediate the influence of type 2 diabetes mellitus on the prognosis of patients with HCC. Guaifenesin Sugarcane pokkah boeng is an economically important fungal disease worldwide, which was first described in Java by Walker and Went in 1896, and the name was a Javanese term denoting a malformed or distorted top. Since then, pokkah boeng has been recorded in almost all cane growing countries, but it only causes severe damage in areas where susceptible varieties are widely planted during a hot and dry season followed by a wet season. Three to seven month-old sugarcane is more susceptible to infection than plants in later stages of growth. After infection, the leaves become crumpled, twisted, and shortened. Irregular reddish stripes and specks then develop within the chlorotic tissue and form lens or rhomboid-shaped holes. Leaf sheaths may also become chlorotic and develop irregular necrotic areas of reddish color. The most serious injury is infection of the growing tip of the plant, which results in the loss of the entire top of plant and is referred to as top rot. Thus, sugarcane pokkah boeng has become a serious threat to sugarcane production in China. In addition, the incidence and severity of pokahh boeng has been reported from major sugarcane growing areas during all seasons, rather than only during the wet and hot summer seasons. Pokkah boeng is caused by the Fusarium species complex, but it is not known which of the large number of species contribute to disease outbreaks. One pathogen responsible for pokkah boeng was first described as Gibberella fujikuroi in 1904. In South Africa, F. sacchari, F. proliferatum, and F. andiyazi were identified as causal agents as a result of inoculation experiments in potted plants. Forty-one isolates of F. verticillioides or F. subglutinans produced symptoms of pokkah boeng.