Adiponectin is the most abundant adipokine produced by adipose tissue. Serum levels of adiponectin are markedly decreased in patients with visceral obesity and states of insulin resistance such as non-alcoholic fatty liver disease and type 2 diabetes. There is an ongoing debate regarding adiponectin’s significance for CAD. Although experimental data do suggest an atheroprotective effect , existing epidemiological data connecting adiponectin and cardiovascular disease are controversial. Low adiponectin levels have been linked to the presence of CAD and were shown to be a risk factor for CAD and cardiovascular events. Low adiponectin levels were reported to be associated with a higher risk of acute coronary syndrome, independent of other traditional metabolic and cardiovascular risk factors. In contrast with the instability of Compound Library Tollip sumoylation, its expression in 293T cells seems to trigger stable modification of proteins other than Tollip, suggesting a general activation of the process following over-expression. One of the cellular proteins constitutively modified by SUMO-1 is the RanGTPase binding protein RanGAP-1, the binding partner of the RanBP2 ligase, a nucleoporine that serves as a docking site for the nuclear import of proteins. Our results show that transfected Tollip co-immunoprecipitates with RanGAP-1, suggesting its role in RanGAP-1 sumoylation and nuclear cytoplasmic traffic. Accordingly, for the first time we show a nuclear localization of Tollip. We do not know what the nuclear function of Tollip may be but we can speculate on some hypothesis. Nuclear Tollip may be important for the sumoylation of nuclear substrates. Alternatively, Tollip could function as a carrier for nuclear localization of sumoylated proteins, as suggested by the interaction with RanGAP-1. The inner ears of all vertebrates detect both auditory and vestibular stimuli to a lesser or greater extent, depending on the species. The region of the ear responsible for detection of rotational motion consists of three orthogonally arranged semicircular canals and their associated sensory patches, the cristae. Angular motion stimuli normally cause displacement of sensory hair cells in the cristae due to the inertia of the fluid in the semicircular canals, and compensatory muscle movements allow an animal to maintain postural equilibrium as it turns. Tollip may be involved in the translocation and nuclear localization of the cytoplasmic portion of a number of membrane receptors, among which the sumoylated cytoplasmic IL-1RI. Sumoylation regulates different cellular processes, particularly transcriptional repression and activation. The regulation of transcription occurs mainly through the recruitment of transcriptional co-repressors that cause downregulation. Daxx is a transcriptional co-repressor interacting with many sumoylated factors leading to SUMO-dependent repression and Daxx interacts with Tollip. Generally, Daxx is localized in the nucleoplasm and in defined nuclear structures, i.e. in the SUMO-modified PML bodies.