Very recently it was shown that PDGFbb binds to the VEGF receptors and affects VEGF-dependent in vitro proliferation. Therefore, this newly described interaction is not unprecedented but still raises questions on its possible significance during vertebrate embryogenesis. It should be noted that the binding affinity is low, which made it difficult to document specificity, but this fact has probably a significance. We 
propose that a low affinity binding for a relatively abundant molecule such as sFRP-3 may represent a way to prevent ligand diffusion outside of its domain of action. It is important to underline that in Drosophila morphogenesis many fate choice decisions are dictated by a competition between the Wg and the EGFR signaling pathways. For example, cells in the Drosophila eye are resistant to apoptosis induced by activated Armadillofor a Labetalol hydrochloride longperiod prior to theonset of celldeath at themidpupal stage. This latency is due to EGF receptor /MAP kinase signaling since when it naturally ceases, the cells rapidly die. Thus, activated Folinic acid calcium salt pentahydrate Armadillo is subject to a specific negative control by EGFR/Rolled MAP kinase signaling. Furthermore, in the ventral epidermis Wingless signaling specifies smooth cells that produce naked cuticle, whereas the activation of the Drosophila epidermal growth factor receptor leads to the production of intercalating cells with cytoplasmic extrusions known as denticles. The DER pathway promotes denticle formation by activating svb expression that is known to induce, cell autonomously, cytoskeletal modifications producing the denticles. Conversely, Wingless promotes the smooth cell fate through the transcriptional repression of svb by the bipartite nuclear factor Armadillo/dTcf. Moreover recent findings show the existence of a cortical region in which EGF family members and the secreted Wnt antagonist sFRP-2 are co-expressed. The identification of a sFRP-3/EGF interaction in vertebrate development outlines a previously unknown developmental mechanism; it also opens a new area of investigation on the specific role of such interaction in the development of vertebrate neuroectoderm and mesoderm. Prostate cancer is the most frequently diagnosed non-cutaneous cancer within the male population of western countries. Epidemiological studies have suggested that diets rich in cruciferous vegetables, such as broccoli, may reduce the risk of prostate cancer.