Glaucoma affects more than 60 million people, and it has been estimated that the disease causes approximately 8 million people to develop bilateral blindness. Primary open-angle glaucoma is the most common type of glaucoma. The death of retinal ganglion cells is crucial to the pathophysiology of all forms of glaucoma. RGCs are a population of central Nodakenin nervous system neurons with soma in the inner retina and axons in the optic nerve. Progressive loss of RGCs and atrophy of the optic nerve 
result in irreversible visual field loss. Alzheimer disease’s is a progressive neurodegenerative disorder characterized by cognitive and memory deterioration, changes in personality, behavioral disturbances, and an impaired ability to perform activities of daily living. As most common form of dementia, AD is a major public health problem worldwide. Glaucoma and AD share several features. Both are slow, chronic neurodegenerative disorders with an age-related incidence. Structural studies have shown that the optic nerves of both POAG and AD patients exhibit degeneration and loss of RGNs. On a molecular level, caspase activation induces abnormal amyloid precursor protein formation, which is the key event in the pathogenesis of AD, were observed in a rat model of chronic ocular hypertension. Although several clinical studies have demonstrated an increased prevalence of POAG in AD patients, large population-based studies have not revealed an association between POAG and AD. Therefore, the relationship between glaucoma and AD remains unclear. The results of our population-based propensity-score-matched cohort study suggested that a clinical diagnosis of POAG increases the risk of developing AD, but not the risk for developing PD. The propensity score matching technique enabled us to identify comparable matched pairs; thus, patients with POAG and nonPOAG matched control patients exhibited similar baseline characteristics. Using this approach prevents the selection bias that occurs in most observational studies and can substantially improve the validity of study results. Previous studies have indicated that the incidence of glaucoma among patients with AD is higher than that of patients without AD. Pseudoexfoliation syndrome is the most important independent risk factor of open angle glaucoma, and the deposition of amyloid-like material in PEX shares some features with the findings in AD. Cumurcu et al reported increased prevalence of AD in patients with PEX comparing to the control groups. They concluded the PEX material deposition in anterior chamber could be a useful finding in early diagnosis of AD. Ekstrom et al included a cohort including 1123 participants of aged 65�C74 years in central Sweden. At the baseline, 246 patients with PEX and 122 patients with newly diagnosed OAG were included.However, they did not find any significant association between PEX and AD or between OAG and AD over 30 years of follow-up. Our findings were consistent with the result of the Three-CityBordeaux-Alienor study that included a cohort of 812 participants who received eye and neuropsychological examination at the start and the end of a 3-year period, and it revealed a 3.9-fold increase in the risk of AD in POAG patients; however, the number of participants who developed dementia over the 3-year study period was Acetylcorynoline relatively low, thus resulting in a wide confidence interval of relative risk. In this current study, the accuracy of claims data substantially influences the findings. Thus, we combined the diagnostic codes and the concurrent medication to increase the accuracy of the diagnosis.